Example plot for ROS1 driver gene

This example plot for the ROS1 driver gene shows the correlation between low imbalance values and samples that do not contain a fusion (in red). Samples that do contain a fusion (in blue) all contain higher imbalance values. For more information on novel fusion detection in Ion Reporter™ Software, see Novel fusion detection using expression imbalance.

Zoomed in view:

• A 3'/5' Imbalance value of 0.5 or greater indicates the likely presence of a ROS1 fusion.

• With a 3'/5' Imbalance value of 0.2, there is no evidence that a ROS1 fusion is present.

• The range of 3'/5' Imbalance values between 0.2 and 0.5 is an area of uncertainty where there is some evidence that a fusion may be present. The higher the imbalance value, the more evidence there is that a ROS1 fusion is present.