JavaScript must be enabled in order to use this site.Please enable JavaScript in your browser and refresh the page. Oncomine™ Breast cfDNA Assay Variant type Oncomine™ gene class Oncomine™ variant class Annotation criteria Missense hotspot mutation Gain-of-Function Loss-of-Function Hotspot Positive mutation call Functional impact is missense Transcript and coding syntax occur in predefined missense hotspot list In-frame hotspot mutation Gain-of-Function Loss-of-Function Hotspot Positive mutation call Function, transcript, and coding syntax occur in predefined in-frame hotspot list Related Topics Parent topic: Oncomine™ Variant Annotator plugin criteria ×